Assembly of extracorporeal circuit with Efferon® device in isolated hemoperfusion mode on MultiFiltrate RRT machine or its analogues.

What do you need?

Plastic bag for priming solution, 2 liter

DIN-Luer bloodline,
2 pcs

0,9% saline solution bag, 1 liter

Heparin,
10.000 МЕ

Clamps,
4 pcs

1

Assemble the extracorporeal
circuit of the RRT machine
according to its user manual.

2

Stop the blood pump and put
clamps on both bloodlines

(“red” one is filled)

3

Add 10.000 ME heparin
to saline solution
and mix
it to prepare the rinsing
solution

4

Connect DIN-Luer bloodline 1 with
priming solution bag.
Fill the
bloodline with the priming solution
using gravity. Attach the clamp to the
bllodline.

5

Mount the Efferon device
in vertical position.**

6

Remove the cap from
bottom port
of the Efferon®
device and connect the
pre-filled DIN-Luer bloodline
1 to it.

7

Remove the cap from upper
port
of the Efferon® device and
connect the empty DIN-Luer
bloodline 2 to it.

8

Connect the plastic bag
for rinsing solution
to DIN-Luer bloodline 2

9

Remove the clamp from
DIN-Luer bloodline 1
and
rinse the Efferon® device
using gravity.

10

Put the clamp on DIN-Luer
bloodline 2
after the priming
is finished.

11

Disconnect the DIN-Luer
bloodline 1 from bottom port

of the Efferon® device

12

And connect the “red”
bloodline of extracorpore-
al circuit to it.

13

Disconnect the “priming”
bloodline DIN-Luer 2
from
upper port of the Efferon®
device

14

And connect the “blue”
bloodline of extracorporeal
circuit to it.

15

The circuit is ready. Remove
all the clamps and start the
blood pump

* If RRT procedure is already being performed and Efferon® device should be installed in previously assembled circuit, stop the procedure, reinfuse the blood and go to recirculationmode.
** Efferon® device is symmetric, flow rate should be oriented from bottom to top.
Anticoagulation level before the start and during
the extracorporeal treatment:
— 160-210 seconds of ACT
— 60-80 seconds of aPTT
Efferon® LPS

Single-use therapeutic device for extracorporeal blood adsorption. Contains polymeric beads surface-modified with LPS-selective ligand.

Efferon® CT

Single-use therapeutic device for extracorporeal blood adsorption. Contains anti-cytokine polymeric beads.