Efferon® LPS

Single-use therapeutic device for extracorporeal blood adsorption. Contains polymeric beads surface-modified with LPS-selective ligand.
INDICATIONS
Sepsis of verified or suspected gram-negative aetiology, including septic shock
Destructive diseases of gastrointestinal tract leading
to LPS translocation
and endotoxemia

Intended use

Device is intended for extracorporeal blood purification by direct hemoperfusion or in combination with hemofiltration. Detoxification is carried out by selective adsorption of lipopolysaccharides (bacterial endotoxins) and excess of endogenous inflammatory mediators.

Timely administration allows to stabilize hemodynamic parameters and prevent development of multiple organ failure.

Polymeric adsorbent
Efferon® LPS.
Concept of action

multimodal adosorbent selectively adsorbs two different therapeutic targets – LPS molecules and excess of cytokines. Cytokines are nonselectively adsorbed in the mesopores of the polymer matrix.
LPS adsorption occurs through interaction with ligand that selectively binds the lipid A moiety of lipopolysaccharide. Novel approach for patients with sepsis efficacy proven by clinical data

How does it work?

Ready to use, sterile and pyrogen-free

Low flow resistance, uniform flow

Tough polycarbonate column

Standard dialysis connectors for perfusion machines

Simple and reliable design eliminates connection errors

Contains suspension of spherical adsorbent beads in isotonic sodium chloride solution

Firm and stable polymer,
does not crumble or dustNo organic impurities emissionHigh hemocompatibility, low thrombogenic activity

Mesoporous structure adsorbs excess of cytokines, myoglobin and other inflammatory mediators

Does not adsorb albumin or larger plasma proteins

LPS selective synthetic ligandCovalent immobilization, no residual emission

Tight LPS binding, long-term efficacy of therapy

Specification

Polymeric adsorbent

Macroporous hypercrosslinked styrene-divinylbenzene copolymer with immobilized LPS-selective ligand, suspension in saline

Total internal volume

210 ml

Adsorbent volume

200 ml

Blood filling volume

50-100 ml

Recommended blood flow rate through the device

100-300 ml/min

Construction

Symmetrical polycarbonate cylinder with two end filters, O-rings and side covers with screw caps

Weight

350 g

Diameter × length

6 × 22 cm

Individual packing

PE / PA bag

Sterilization

radiation sterilization

Efferon® LPS

Single-use therapeutic device for extracorporeal blood adsorption. Contains polymeric beads surface-modified with LPS-selective ligand.

Efferon® CT

Single-use therapeutic device for extracorporeal blood adsorption. Contains anti-cytokine polymeric beads.

Contact us

Find out more
about Efferon®

+ 7 495 150 39 17
mail@efferon.com

143026, Russia, Moscow,
Skolkovo, st. Nobel, 7