Assembly of extracorporeal circuit with Efferon® device and hemofilter in “POSTfilter” mode on PrismaFlex RRT machine

What do you need?

0,9% saline solution bag, 1 liter

Plastic bag for priming solution,
2 liter

DIN-Luer bloodline,
2 pcs

Heparin,
10.000 ME

Luer-Luer
adapter

Clamps,
4 pcs

1

Assemble the extracorporeal circuit of the RRT machine
according to its user manual.

2

Add 10.000 ME heparin to saline solution and mix it to prepare the rinsing solution.

3

Connect DIN-Luer bloodline 1 with priming solution bag. Fill the bloodline with the priming solution using gravity. Attach the clamp to the bllodline.

4

Mount the Efferon® device in vertical position.** .

5

Remove the cap from bottom port of the Efferon® device and connect the pre-filled DIN-Luer bloodline 1 to it.

6

Remove the cap from upper port of the Efferon® device and connect the empty DIN-Luer bloodline 2 to it.

7

Connect the plastic bag for rinsing solution to DIN-Luer bloodline 2.

8

Remove the clamp from DIN-Luer bloodline 1 and rinse the Efferon® device using gravity

9

Put the clamps to DIN-Luer bloodlines 1 and 2 after the priming is finished

10

Disconnect the plastic bags from DIN-Luer bloodlines 1 and 2 and utilize it

11

Connect the Luer-Luer
adapter to DIN-Luer bloodline 2

12

Stop the blood pump
of RRT machine

13

Put the clamps on inlet
and outlet bloodlines
of the hemofilter

14

Disconnect the extracorporeal
circuit
between the hemofilter
outlet and air bubble trap.

15

Сonnect the bloodlinesin a sequence: DIN-Luer bloodline 1 is attached to the hemofilter, and Luer-Luer adapter is attached to the air bubble trap.

16

The circuit is ready. Remove all the clamps and start the blood pump.

* If RRT procedure is already being performed and Efferon® device should be installed in previously assembled circuit, stop the procedure, reinfuse the blood and go to recirculationmode..
** Efferon® device is symmetric, flow rate should be oriented from bottom to top.
Anticoagulation level before the start and during
the extracorporeal treatment:
— 160-210 seconds of ACT
— 60-80 seconds of aPTT
Recommended duration of use is 4-6 hours (up to 12 hours)
Efferon® LPS

Single-use therapeutic device for extracorporeal blood adsorption. Contains polymeric beads surface-modified with LPS-selective ligand.

Efferon® CT

Single-use therapeutic device for extracorporeal blood adsorption. Contains anti-cytokine polymeric beads.