Assembly of extracorporeal circuit with Efferon® device and hemofilter in “PREfilter” mode on MultiFiltrate RRT machine or its analogues

What do you need?

0,9% saline solution bag, 1 liter

Plastic bag for priming solution, 2 liter

DIN-Luer bloodline,
2 pcs

Heparin,
10.000 ME

DIN-DIN
bloodline

Clamps,
4 pcs

1

Assemble the extracorporeal
circuit of the RRT machine

according to its user manual.

2

Add 10.000 ME heparin
to saline solution
and mix
it to prepare the rinsing
solution.

3

Connect DIN-Luer bloodline 1
with priming solution bag.

Fill the bloodline with the priming
solution using gravity. Attach
the clamp to the bllodline

4

Mount the Efferon® device
in vertical position.**

5

Remove the cap from bottom port of
the Efferon® device and connect the
pre-filled DIN-Luer bloodline 1 to it.

6

Remove the cap from upper
port
of the Efferon® device and
connect the empty DIN-Luer
bloodline 2 to it.

7

Connect the plastic bag for
rinsing solution to DIN-Luer
bloodline 2.

8

Remove the clamp from
DIN-Luer bloodline 1
and
rinse the Efferon® device
using gravity.

9

Put the clamp on DIN-Luer bloodline 1 and 2 after the priming is finished.

10

Disconnect DIN-Luer
bloodline 2
from the
upper port of the Efferon®
device and attach
DIN-DIN bloodline to it

11

Remove the clamp from the DIN-Luer bloodline 1. Fill the DIN-DIN bloodline with priming solution, then attach the clamps to both blood- lines.

12

Stop the blood pump
of RRT machine

13

Put the clamps on inlet
and outlet bloodlines

of the hemofilter

14

Disconnect the DIN-Luer
bloodline 1
from bottom port
of the Efferon® device. Take
care of air bubbles not
to enter inside.

15

Disconnect the “red”
bloodline
at the inlet
of the hemofilter

16

And connect it to lower
port
of the Efferon® device

17

Connect the DIN-DIN
bloodline and inlet port
of hemofilter.

18

The circuit is ready.
Remove all the clamps
and start the blood pump.

* If RRT procedure is already being performed and Efferon® device should be installed in previously assembled circuit, stop the procedure, reinfuse the blood and go to recirculation mode.
** Efferon® device is symmetric, flow rate should be oriented from bottom to top.
Anticoagulation level before the start and during
the extracorporeal treatment:
— 160-210 seconds of ACT
— 60-80 seconds of aPTT
Recommended duration of use is 4-6 hours
(up to 12 hours)
Efferon® LPS

Single-use therapeutic device for extracorporeal blood adsorption. Contains polymeric beads surface-modified with LPS-selective ligand.

Efferon® CT

Single-use therapeutic device for extracorporeal blood adsorption. Contains anti-cytokine polymeric beads.