Assembly of extracorporeal circuit with Efferon® device and hemofilter in “PREfilter” mode on MultiFiltrate RRT machine or its analogues

What do you need?

0,9% saline solution bag, 1 liter

Plastic bag for priming solution, 2 liter

DIN-Luer bloodline,
2 pcs

Heparin,
10.000 ME

DIN-DIN
bloodline

Clamps,
4 pcs

1

Assemble the extracorporeal
circuit of the RRT machine

according to its user manual.

2

Add 10.000 ME heparin
to saline solution
and mix
it to prepare the rinsing
solution.

3

Connect DIN-Luer bloodline 1
with priming solution bag.

Fill the bloodline with the priming
solution using gravity. Attach
the clamp to the bllodline

4

Mount the Efferon® device
in vertical position.**

5

Remove the cap from bottom port of
the Efferon® device and connect the
pre-filled DIN-Luer bloodline 1 to it.

6

Remove the cap from upper
port
of the Efferon® device and
connect the empty DIN-Luer
bloodline 2 to it.

7

Connect the plastic bag for
rinsing solution to DIN-Luer
bloodline 2.

8

Remove the clamp from
DIN-Luer bloodline 1
and
rinse the Efferon® device
using gravity.

9

Put the clamp on DIN-Luer
bloodline 1
after the priming
is finished.

10

Disconnect DIN-Luer
bloodline 2
from the
upper port of the Efferon®
device and attach
DIN-DIN bloodline to it

11

Remove the clamp from
the DIN-Luer bloodline 1.
Fill the DIN-DIN bloodline
with priming solution, then
attach the clamps to both
bloodlines

12

Stop the blood pump
of RRT machine

13

Put the clamps on inlet
and outlet bloodlines

of the hemofilter

14

Disconnect the DIN-Luer
bloodline 1
from bottom port
of the Efferon® device. Take
care of air bubbles not
to enter inside.

15

Disconnect the “red”
bloodline
at the inlet
of the hemofilter

16

And connect it to lower
port
of the Efferon® device

17

Connect the DIN-DIN
bloodline and inlet port
of hemofilter.

18

The circuit is ready.
Remove all the clamps
and start the blood pump.

* If RRT procedure is already being performed and Efferon® device should be installed in previously assembled circuit, stop the procedure, reinfuse the blood and go to recirculation mode.
** Efferon® device is symmetric, flow rate should be oriented from bottom to top.
Anticoagulation level before the start and during
the extracorporeal treatment:
— 160-210 seconds of ACT
— 60-80 seconds of aPTT
Recommended duration of use is 4-6 hours
(up to 12 hours)
Efferon® LPS

Single-use therapeutic device for extracorporeal blood adsorption. Contains polymeric beads surface-modified with LPS-selective ligand.

Efferon® CT

Single-use therapeutic device for extracorporeal blood adsorption. Contains anti-cytokine polymeric beads.