Setup Guide for Integrating Efferon® Device into the Cardiopulmonary Bypass (CPB) Circuit

What do you need?

0.9% saline solution
bag, 1lite

Plastic bag for priming
solution, 2 lite

DIN-Luer bloodlines,
2 pcs

Heparin,
10 000 IU

Clamps,
4 pcs

1

Assemble the
extracorporeal circuit
of the CPB machine
according to its user
manual

2

Add 10,000 IU of
heparin to 0.9% saline
solution and mix it

3

Connect the DIN-Luer bloodline 1 to the priming solution bag. Fill the bloodline with the priming solution using gravity. Attach a clamp.

4

Mount the Efferon® device (hereinafter “the device”) vertically in the holder.*

5

Remove the cap from the bottom (arterial) port of the device and connect the pre-filled DIN-Luer bloodline 2 to it.
For convenience, the device may be inverted so that the arterial port is oriented upward. Once
connected, return the device to its original position with the upper (venous) port facing upward.

6

Remove the cap from the
upper port of the device and
connect the DIN-Luer
bloodline 2 to it.

7

Connect the plastic bag for rinsing solution to the DIN- Luer bloodline 2.

8

Remove the clamp from
DIN-Luer bloodline 1 and
rinse the device using
gravity.

9

Put the clamps to both
DIN-Luer bloodlines 1
and 2 after the priming
is finished.

10

Disconnect DIN-Luer bloodline 1 from the priming solution bag and connect the bloodline 1 to the oxygenator.

11

Connect the DIN-Luer bloodline 2 to the cardiotomy reservoir connector of the CPB machine.

12

Once the procedure has started, remove the clamps from the DIN-Luer bloodlines 1 and 2.

* Note: The fluid flow direction through the Efferon® device must be from bottom to top both during priming and treatment.

Efferon® LPS

Single-use therapeutic device for extracorporeal blood adsorption. Contains polymeric beads surface-modified with LPS-selective ligand.